The present invention is generally directed to methods of producing an increase in the enrichment and/or recovery of preferred forms of monoclonal antibodies. More particularly, the invention relates to methods for eliminating disulfide heterogeneity in the hinge region of recombinant IgG2 antibody proteins.
申请公布号
AU2013203141(B2)
申请公布日期
2016.06.30
申请号
AU20130203141
申请日期
2013.04.09
申请人
AMGEN INC.
发明人
DILLON, THOMAS M.;BONDARENKO, PAVEL;WYPYCH, JETTE;ALLEN, MARTIN;BALLAND, ALAIN;RICCI, MARGARET SPEED;GUO, AMY;SHEN, WENYAN;SUN, JEONGHOON;VEZINA, CHRIS
