| 发明名称 |
BIOMARKERS CORRELATED TO PARP INHIBITOR TREATMENT SUCCESS IN AML PATIENTS |
| 摘要 |
In one aspect, there is provided a method for predicting responsiveness of a subject to a poly-(ADP-ribose)-polymerase (PARP) inhibitor for treating acute myeloid leukaemia (AML), the method comprising determining whether a chromosomal abnormality selected from t(8;21), t(15;17), t(16;16) and inv(16) is present in a sample obtained from the subject; wherein the presence of the chromosomal abnormality is indicative of responsiveness of the subject to the PARP inhibitor for treating AML. |
| 申请公布号 |
US2016208339(A1) |
申请公布日期 |
2016.07.21 |
| 申请号 |
US201415022637 |
申请日期 |
2014.09.17 |
| 申请人 |
KING'S COLLEGE LONDON |
发明人 |
So Chi Wai Eric;Esposito Maria Teresa |
| 分类号 |
C12Q1/68;A61K31/4184;A61K45/06;A61K31/502 |
主分类号 |
C12Q1/68 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for predicting responsiveness of a subject to a poly-(ADP-ribose)-polymerase (PARP) inhibitor for treating acute myeloid leukaemia (AML), the method comprising determining whether a chromosomal abnormality selected from t(8;21), t(15;17), t(16;16) and inv(16) is present in a sample obtained from the subject; wherein the presence of the chromosomal abnormality is indicative of responsiveness of the subject to the PARP inhibitor for treating AML. |
| 地址 |
London GB |
