| 摘要 |
The present invention relates to a method for the in vitro detection of the presence in a biological sample of at least one rare nucleic acid from a microorganism or a virus, said method comprising the preparation of a sample of nucleic acids comprising a treatment with a double-strand specific nuclease which relatively decreases the amount of predominant double stranded DNA molecules and increases the proportion of rare nucleic acid molecules. The present invention also relates to the use of a double-strand specific nuclease for preparing a sample comprising nucleic acid molecules, and for the characterization of a biological product. |
