Methode für die Synthese eines Peptides, das eine nicht peptidartige Bindung enthält.
摘要
This invention features a method for the solid phase synthesis of non-peptide bonds (CH2-NH) in polypeptide chains. These polypeptides are synthesized by standard procedures and the non-peptide bond synthesized by reacting an amino aldehyde and an amino acid in the presence of NaCNBH3. This invention also features somatostatin analogs with non peptide bonds. This invention further features a solid phase method of chemically modifying a peptide. The method involves synthesizing alpha -N-R and side group N-R analogs of peptides, where R is an alkyl or aryl group, by reacting a carbonyl- containing compound and an amino acid in the presence of NaCNBH3.
申请公布号
DE3788910(D1)
申请公布日期
1994.03.10
申请号
DE19873788910
申请日期
1987.06.26
申请人
THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, NEW ORLEANS, LA., US
发明人
COY, DAVID H., NEW ORLEANS LOUISIANA 70115, US;HOCART, SIMON J., NEW ORLEANS LOUISIANA 70122, US