发明名称 |
BIOSYNTHESIS METHOD ENABLING THE PREPARATION OF COBALAMINS |
摘要 |
In the biosynthesis of cobalamines (A) by fermenting an appropriate prokaryotic microorganism, the new feature is: (a) the microorganism is transformed with /- 1 DNA fragment encoding an enzyme involved in biosynthesis of O-phospho-L-threonine (I); (b) (I) is added to the culture medium or (c) aerobic producing organisms are transformed with /- 1 DNA fragment encoding an enzyme involved in biosynthesis of 5,6-dimethylbenzimidazole (II). Also claimed are microorganisms of (a) and (c). |
申请公布号 |
HU9902730(A2) |
申请公布日期 |
1999.12.28 |
申请号 |
HU19990002730 |
申请日期 |
1997.05.05 |
申请人 |
RHONE-POULENC Rorer S.A. |
发明人 |
BLANCHE, FRANCIS;CAMERON, BEATRICE;CROUZET, JOEL;DEBUSSCHE, LAURENT;REMY, ELISABETH;THIBAUT, DENIS |
分类号 |
C12N15/09;C12N1/19;C12N15/52;C12P19/42;C12R1/38 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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