Hexahydro-2-oxo-1H-thieno (3,4-d) imidazole-4-pentanoic acid preparation from benzylated analog using inexpensive sulfuric acid, used e.g. as food or feed additive

摘要

Preparation of hexahydro-2-oxo-1H-thieno (3,4-d) imidazole-4-pentanoic acid (I) involves contacting a 1- and/or 3-benzylated analog (or a corresponding dicarboxylic acid) (II) with sulfuric acid in presence of an aromatic hydrocarbon. Preparation of hexahydro-2-oxo-1H-thieno (3,4-d) imidazole-4-pentanoic acid of formula (I) involves contacting a benzylated analog of formula (II) with sulfuric acid in presence of an aromatic hydrocarbon. R1, R2 = H or benzyl, but not both H; R3 = H or COOH.