ISOLATION OF MICROMONOSPORA CARBONACEA VAR AFRICANA PMLP1 INTEGRASE AND USE OF INTEGRATING FUNCTION FOR SITE-SPECIFIC INTEGRATION INTO MICROMONOSPORA HALOPHITICA AND MICROMONOSPORA CARBONACEA CHROMOSOME

摘要

Plasmid genes from Micromonospora carbonacea var. africana ATCC39149 pMLP1 have been isolated cloned, sequenced and functionally identified. These genes have been used to create vectors which integrate in a site-specific manner into the host chromosome of actinomycete species.