ANTIBODIES AGAINST FCRN AND USE THEREOF

摘要

This disclosure provides, inter alia, proteins that bind to FcRn, e.g., immunoglobulins that inhibit FcRn with high affinity and selectivity. The FcRn-binding proteins can be used to treat a variety of disorders including autoinmune disorders. See Fig. 36. WO 2009/131702 PCT/US2009/002536 - (a, z) ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS - (a, z) GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKK - (f) ----------------------------------------------- - (a, z) VEIPKS...T HTPPCAPELLGGPSVFLFPPKPKDTLMISRT PEVTCVVV - (a, z) D - (a, z) LN G KEYKCKVSNiKALPAVI FKITI SKAKGQPREPQVYTLPPSPREPQVYT - (a,z) LPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLD - (f)------E-M--------------------------------------- - (a,z) SDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK* - ----------------------------------- ~---~~~~ (a, z) (SEQ ID NO: 115) (f) (SEQ ID NO: 116) SUBSTITUTE SHEET (RULE 26)