发明名称 |
ALOE-EMODIN DERIVATIVES AND THEIR USE IN THE TREATMENT OF NEOPLASTIC PATHOLOGIES |
摘要 |
The invention relates to aloe-emodin (AE) derivatives and their use as anticancer drugs. Saids derivatives show a specific cytotoxicity to tumour cells, also of neuroectodermal origin, to which they may in particular act a s aloe-emodin prodrugs. Said pharamcological profile makes them particularly suitable for use in the treatment of neoplasias. Thereofore, pharmaceutical compositions containing said compound may be usefully used in the treatment of neoplasias. It has surprisingly been found that aloe-emodin derivatives in position 3' (bearing either a positive or negaive charge) exhibit improved sollubility properties and, at the same time, in vitro show cytotoxicity to tumour cells, also of neuroectodermal origin.
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申请公布号 |
CA2446429(A1) |
申请公布日期 |
2002.11.14 |
申请号 |
CA20022446429 |
申请日期 |
2002.05.10 |
申请人 |
UNIVERSITA' DEGLI STUDI DI PADOVA |
发明人 |
PECERE, TERESA;ZAGOTTO, GIUSEPPE;CARLI, MODESTO;PALU', GIORGIO |
分类号 |
A61K9/16;A61K9/20;A61K9/48;A61K31/223;A61K31/225;A61K31/405;A61K31/661;A61K31/704;A61P35/00;C07C69/00;C07C69/40;C07C69/60;C07C69/80;C07C229/08;C07C229/22;C07C229/36;C07D209/20;C07F9/09;C07F9/113;C07H15/244;(IPC1-7):C07C69/017 |
主分类号 |
A61K9/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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