摘要 |
<p>The present invention relates to novel alkanoyl-substituted heterocyclic derivatives which are cysteine protease inhibitors; the pharmaceutically acceptable salts and N-oxides thereof; their uses as therapeutic agents and the methods of their making; according to Formal (I) in which: A comprises a heteromonocyclic ring containing 5 to 6 ring member atoms or a fused heteropolycyclic ring system containing 8 to 14 ring member atoms, wherein each ring contains 5 to 7 ring member atoms, X<1> is a ring member carbon atom and each ring member other than X<1> is a carbon atom or a heteroatom, with the proviso that (i) at least one ring member atom is a heteroatom and (ii) when A is a heteromonocyclic radical containing 5 ring member atoms, no more than two of the ring member atoms comprising A are heteroatoms; n is 0, 1, 2 or 3; X<1> is =C- or -CH-; X<2> is a bond or a divalent group of Formula (a) or (b); R<1> - R<8>= as in the application.</p> |
申请人 |
AXYS PHARMACEUTICALS, INC. |
发明人 |
MARTICHONOK, VALERI;BURGESS-HENRY, JANA;GRAUPE, MICHAEL;LINK, JOHN O.;MCDOWELL, ROBERT S.;MCGRATH, MARY E.;MOSSMAN, CRAIG J.;PATTERSON, JOHN W.;SAUNDERS, OLIVER L.;ZIPFEL, SHEILA M.;MARTELLI, ARNOLD J.;LAI, JUSTINE;ALDOUS, DAVID J.;HALLEY, FRANK;PICKETT, STEPHEN D.;THURAIRATNAM, SUKANTHINI;TIMM, ANDREAS P. |