NUCLEIC ACID COMPOUNDS FOR INHIBITING MET GENE EXPRESSION AND USES THEREOF
摘要
The present disclosure provides meroduplex ribonucleic acid molecules (mdRNA) capable of decreasing or silencing c-Met gene expression. An mdRNA of this disclosure comprises at least three strands that combine to form at least two non-overlapping double-stranded regions separated by a nick or gap wherein one strand is complementary to a MET mRNA. In addition, the meroduplex may have at least one uridine is a 5-methyluridine, a nucleoside is a locked nucleic acid, or optionally other modifications, and any combination thereof. Also provided are methods of decreasing expression of a MET gene in a cell or in a subject to treat a MET-related disease.
申请公布号
WO2008109447(A1)
申请公布日期
2008.09.12
申请号
WO2008US55511
申请日期
2008.02.29
申请人
NASTECH PHARMACEUTICAL COMPANY INC.;QUAY, STEVEN, C.;MCSWIGGEN, JAMES;VAISH, NARENDRA, K.;AHMADIAN, MOHAMMAD
发明人
QUAY, STEVEN, C.;MCSWIGGEN, JAMES;VAISH, NARENDRA, K.;AHMADIAN, MOHAMMAD