发明名称 |
HIGH ISOMEROHYDROLASE ACTIVITY MUTANTS OF MAMMALIAN RPE65 |
摘要 |
Mutant mammalian RPE65 proteins and portions thereof, and nucleic acids encoding the mutants, for use in treating a condition related to retinal degeneration in a subject, the mutant mammalian RPE65 proteins or portions thereof having isomerohydrolase activity. A gene therapy method of treating a condition related to retinal degeneration in a mammalian subject in need of such treatment, comprising administering to the subject a therapeutically- effective amount of a vector comprising a nucleic acid encoding a mutant mammalian RPE65 protein or a portion thereof. A method of treating a condition related to retinal degeneration in a subject in need of such treatment, comprising administering to the subject a therapeutically-effective amount of at least one of a mutant mammalian RPE65 protein or a portion thereof. |
申请公布号 |
SG11201700724P(A) |
申请公布日期 |
2017.02.27 |
申请号 |
SG11201700724P |
申请日期 |
2015.07.27 |
申请人 |
THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA |
发明人 |
MA, JIAN-XING;TAKAHASHI, YUSUKE;MOISEYEV, GENNADIY |
分类号 |
A61K48/00;A01N63/00 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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