Bis-(triethylphosphine)platinum(II) complexes with thiones as anti cancer agents

摘要

Platinum(II) complexes having mixed ligands as anticancer agents. The central platinum atom is coordinated by two phosphine ligands and two heterocyclic thione ligands. Each heterocyclic thione ligand has a five-, six- or seven-membered heterocyclic ring with two nitrogen atoms at positions 1 and 3 of the ring and a thiocarbonyl group at position 2. Pharmaceutical compositions incorporated the platinum(II) complexes, methods of synthesizing the complexes and methods of treating cancers with the complexes or pharmaceutical compositions thereof are also described.

主权项

1. A platinum(II) complex of Formula I, Formula II, Formula III, Formula IV, Formula V or Formula VI: or a pharmaceutically acceptable salt, tautomer, ester, or solvate thereof; where R1-R18 are each independently a hydrogen atom, a halogen atom, an optionally substituted C1-C3 alkyl group, an optionally substituted C1-C3 alkoxy group, an optionally substituted C2-C3 alkenyl group or an optionally substituted C2-C3 alkynyl group.