| 摘要 |
A method for preparing a zaltoprofen salt is provided to heighten the solubility of the zaltoprofen salt in water, enhance absorption and perform the bioequivalent test and bioavailability analysis. A zaltoprofen salt is manufactured by resolving a zaltoprofen of the chemical formula 1 in methanol, ethanol, propanol, isopropanol, butanol, isobutanol or t-butanol solvent and adding base(MOH) of equal equivalent. The reaction temperature is 0°C-40°C and time is 30 minutes to 4 hours. The base is NaHCO3, Na2CO3, NaOH, KOH, BaOH or LiOH. The zaltoprofen salt is washed with acetone or isopropyl ether solvent. A method of bioequivalent test and bioavailability analysis is performed by using a HPLC (high performance liquid chromatography) including a analysis column, pre-column and trap-column. A moving phase of the pump A which is used in the HPLC system is a mixture of acetonitrile and 10Mm of potassium phosphate buffer in a capacity ratio of 12:88. A moving phase of the pump B is a mixture of acetonitrile and 10Mm of potassium phosphate buffer in a capacity ratio of 35:65. The column flow rate of the pump A and B is 500mul/min and 90mul/min, respectively.
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