Double-structured tissue implant and a method for preparation and use thereof

摘要

A double-structured tissue implant and a method for preparation and use thereof for implantation into tissue defects. The double-structured tissue implant comprising a primary scaffold comprised of collagen and a secondary scaffold comprising a soluble collagen solution in combination with a surfactant generated and positioned within the primary scaffold. A process for preparation of the double-structured implant or the stand alone secondary scaffold comprising lyophilization and dehydrothermal treatment.

主权项

1. A method of making a double-structured tissue implant, the method comprising:
obtaining a primary scaffold comprising collagen, the primary scaffold comprising a porous structure having a plurality of pores; preparing a composition comprising a second collagen and a surfactant; introducing the composition into the plurality of pores of the primary scaffold; and stabilizing the composition within the plurality of pores of the primary scaffold, thereby producing a double-structured tissue implant, wherein the stabilizing step comprises precipitation, dehydration, and lyophilization.