| 发明名称 | Methods for treating liver inflammation in a subject suffering from non-alcoholic steatohepatitis | ||
| 摘要 | The invention is in the field of prevention and medical treatment of liver diseases, in particular non-alcoholic steatohepatitis (NASH). The invention provides means and methods for the treatment of hepatic inflammation, fibrosis and more in particular NASH. More in particular, the invention provides a composition capable of raising anti-oxLDL antibodies in vivo for use in the treatment of liver inflammation or fibrosis. | ||
| 申请公布号 | US9393303(B2) | 申请公布日期 | 2016.07.19 |
| 申请号 | US201214000850 | 申请日期 | 2012.02.21 |
| 申请人 | Universiteit Maastricht;Academisch Ziekenhuis Maastricht | 发明人 | Sverdlov Ronit;Bieghs Veerle;van Gorp Patrick Johannes Jacobus |
| 分类号 | A61K39/00;A61K39/395;A61K39/02;A61K39/09;A61P1/16;C07K16/18;C07K16/12 | 主分类号 | A61K39/00 |
| 代理机构 | TraskBritt, P.C. | 代理人 | TraskBritt, P.C. |
| 主权项 | 1. A method for the treatment of a subject suffering from non-alcoholic steatohepatitis liver inflammation; the method comprising: administering to the subject a composition that passively or actively immunizes the subject against oxidized low density lipoprotein; so as to treat the liver inflammation in the subject as may be determined by a decreased level of tumor necrosis factor, interleukin-1beta, interleukin 6, or monocyte chemoattractant protein-1 in the liver of the subject. | ||
| 地址 | Maastricht NL | ||