Nanoscale platinum compounds and methods of use thereof

摘要

The invention is directed to biocompatible conjugated polymer nanoparticles including a copolymer backbone, a plurality of sidechains covalently linked to said backbone, and a plurality of platinum compounds dissociably linked to said backbone. The invention is also directed to dicarbonyl-lipid compounds wherein a platinum compound is dissociably linked to the dicarbonyl compound. The invention is also directed to methods of treating cancer or metastasis. The methods includes selecting a subject in need of treatment for cancer or metastasis and administering to the subject an effective amount of any of the nanoparticles, compounds, or compositions of the invention.

主权项

1. A conjugate comprising:
a dicarbonyl molecule, wherein a platinum compound is dissociably linked to the dicarbonyl molecule; and a lipid molecule, wherein the dicarbonyl molecule is covalently linked to the lipid molecule, wherein the dicarbonyl molecule is R′OC(O)—R—C(O)—, wherein R is C1-C6 alkylene, wherein the alkylene can comprise one or more double or triple bonds and/or the backbone of the alkylene can be interrupted with one or more of O, S, S(O), SO2, NH, C(O); and R′ is H, alkyl, alkenyl, alkynyl, aryl, heteroaryl, acylcyl, heterocyclyl, each of which can be optionally substituted; and wherein the platinum compound is dissociably linked to the dicarbonyl molecule by a monocarboxylato bond and a Pt<->O coordinate bond.