2, 6-Di-Nitrogen-Containing Substituted Purine Derivative, And Preparation Method, Pharmaceutical Composition And Use Thereof

摘要

The present invention provides a 2, 6-di-nitrogen-containing substituted purine derivative having a formula (I) structure, or pharmaceutical salt or hydrate thereof, and preparation method and use thereof. The compound is broad spectrum anticancer, low toxicity, high anticancer activity and good stability.;

主权项

1. 2, 6-dinitrogen-containing substituted purine derivatives or pharmaceutical salts or hydrate thereof, is characterized in that, the compound of formula (I) is: wherein, R1 represents unsubstituted C1˜C6 straight or branched alkyl; or C1˜C6 straight or branched alkyl substituted by methoxyl, C3˜C6-cycloalkyl, hydroxyl or amino; or unsubstituted C3˜C6-cycloalkyl; or C3˜C6-cycloalkyl substituted by carboxylic carbomethoxy or carboxylic; or phenyl substituted by methoxy; unsubstituted morpholinyl; unsubstituted piperazinyl; unsubstituted piperidyl; piperidyl substituted by hydroxyl or acylamino; unsubstituted pyrrolidinyl; R2 is H; R3 represents H, tetrahydropyrane, trifluoroethyl, piperidyl; R4 represents H, unsubstituted C1˜C6 straight alkyl; unsubstituted C3˜C6 cycloalkyl; unsubstituted phenyl, phenyl substituted by carboxylic carbomethoxy, C1˜C6 straight alkoxy, bis-C1˜C6 straight alkoxy, C1˜C6 straight alkyl sulphanyl or halogen atoms; 1,3-benzodioxol; unsubstituted morpholinyl; unsubstituted piperazinyl; or piperazinyl substituted by methyl; A represents N or O; when A is N, R4 is not equal to H.