PEPTIDYL NITRIL COMPOUNDS AS DIPEPTIDYL PEPTIDASE I INHIBITORS

摘要

The invention relates to compounds of Formula (I) and their use as selective dipeptidyl peptidase I inhibitors, as well as pharmaceutical compositions comprising said compounds, and methods of treatment involving said compounds.;

主权项

1. A compound of the formula (I) wherein X1 represents wherein y represents 0, 1, 2, 3, 4, 5, 6, 7 or 8; wherein Z represents O (oxygen); when y is 1 or 2, then R1 independently represents deuterium; halogen; hydroxyl; cyano; oxo (═O); mercapto; or C1-3-alkyl; which C1-3-alkyl is optionally substituted with at least one substituent selected from halogen, hydroxyl, cyano and mercapto; or when y represents 3, 4, 5, 6, 7 or 8, then R1 represents deuterium; wherein R2 represents —C3-6-cycloalkyl, —C1-3-alkyl-C3-6-cycloalkyl or —C1-6-alkyl, which —C1-6-alkyl is optionally substituted with at least one substituent selected from hydroxyl, cyano or amino; as well as pharmaceutically-acceptable salts thereof.