| 发明名称 | DNA vaccine for use in pancreatic cancer patients | ||
| 摘要 | The present invention relates to an attenuated mutant strain of Salmonella comprising a recombinant DNA molecule encoding a VEGF receptor protein. In particular, the present invention relate to the use of said attenuated mutant strain of Salmonella in cancer immunotherapy. | ||
| 申请公布号 | US9415098(B2) | 申请公布日期 | 2016.08.16 |
| 申请号 | US201314409434 | 申请日期 | 2013.06.26 |
| 申请人 | VAXIMM AG | 发明人 | Lubenau Heinz |
| 分类号 | A61K39/112;C07K14/71;A61K31/7068;A61K39/00 | 主分类号 | A61K39/112 |
| 代理机构 | Foley & Lardner LLP | 代理人 | Foley & Lardner LLP ;Konski Antoinette F.;Nola-Baron Liliana Di |
| 主权项 | 1. A method of treating pancreatic cancer comprising administering to a patient in need thereof a vaccine comprising an attenuated mutant strain of Salmonella typhi Ty21a comprising at least one copy of a recombinant DNA molecule comprising an expression cassette encoding a VEGF receptor protein having the amino acid sequence as found in SEQ ID NO 1, wherein the vaccine is administered in a single dose of 1×109 CFU or less than 1×109 CFU. | ||
| 地址 | Basel CH | ||