POLYCYCLIC CARBAMOYLPYRIDONE DERIVATIVE HAVING HIV INTEGRASE INHIBITORY ACTIVITY

摘要

PROBLEM TO BE SOLVED: To provide an anti-HIV agent having an anti-viral activity, particularly an HIV integrase inhibitory activity.

SOLUTION: The invention relates to the compound represented by formula (I) and the anti-HIV agent containing the same. (Wherein Z1is NR4, R1is a H or a lower alkyl, X is a single bond, a heteroatom group selected from O, S, SO, SO2and NH, or a lower alkylene or a lower alkenylene each may be intervened by the heteroatom group, R2is an optionally substituted aryl, R3is a H, a halogen, a hydroxyl, an optionally substituted lower alkyl, etc., R4and Z2couple and form a polycyclic ring compound (for example, includes a tricyclic ring or a tetracyclic ring compound)).

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