摘要 |
<p>Method for the preparation of nitro-estratrienes of the general formula (I):- (where R = H, opt. substituted C1-6 alkyl, C5-6 cycloalkyl, C1-10 aliphatic or cycloaliphatic acyl; R' = H, mono or dicarbonic acid or C1-10 cycloaliphatic acyl group; R" = H, or C1-4 alkyl; or OR' + R" = oxygen). Estrogenic, antigonadotropic, antiovulatory activity, being particularly active orally.</p> |