CEPHALOSPORIN DERIVATIVES

摘要

A process is disclosed for the preparation of a 7 beta -(4-carboxybutanamide) ceph-3-3em-4-carboxylic acid or a 7 beta -(5-carboxy-5-oxopentamido) ceph-3-em-4-carboxylic acid by subjecting a 7 beta -(D-5-amino-5-carboxypentamido) ceph-2-em-4-carboxylic acid to the action of a cell-free fungal D-amino acid oxidase. The modified cephalosporin compounds produced exhibit antimicrobial activity and are useful as presursors in the synthesis of 7-aminocephalosporanic acid and 7 beta -acylamido analogues of cephalosporin C.