| 摘要 |
<p>N-(3-aminoalkyl-2-oxo-2H-1-Benzopyran-7-yl) ureas- as coronary vasodilators. Cpds (I) and their salts. (where R1, R2, R5 and R6 are H, 1-4C alkyl opt.-OH substd. cycloalkyl, aralkyl or aryl opt substd. by one or two halogen, alkyl, alkoxy, OH or CF3, or NR1R2 and NR5R6 are 3-7 membered heterocyclic rings opt. contg. 1-3-hetero atoms and opt substd. by aryl alkyl opt OH substd. halogen or CF3 R4 is H or 1-3C alkyl, R7 is H, aryl or 1-3C alkyl, Z is halogen, 1-3C -alkyl or alkoxy, n is 0, 1 or 2, and U is 2-5C alkylene opt. OH substd) are prepd. by a number of methods involving the formation of the amino gps. NR1R2 and NR5R6 or the formation of the urea residue.</p> |
