| 摘要 |
PURPOSE:To obtain a malaria vaccine, by attenuating a malaria protozoan, inoculating it to a vertebrate animal of thymus imcompetence, collecting the erythrocyte containing the attenuated malaria protozoan. CONSTITUTION:A mouse, aotus, etc. is infected by a malaria protozoan (e.g., plasmodium berghei, plasmodium falciparum, etc.), the erythrocyte is irradiated with X-rays and the malaria protozoan is attenuated. It is then inculated into a vertebrate animal (e.g., mouse, aotus, etc.) of thymus incompetence. Preferably 15-40 days after the inoculation, its erythrocyte is separated and collected. The prepared erythrocyte containing the attenuated malaria notozoan is directly preserved at preferably -100--50 deg.C, and used as a vaccine. A dose is 10<4>- 10<7> (erythrocyte)/kg weight one - twice in intravenous, intraperitoneal, intramuscular, and hypodermic medication. |
