发明名称 |
Kv BETA 1.1-DEFICIENT MICE WITH IMPAIRED LEARNING |
摘要 |
This invention pertains to the discovery that a mutation disabling the Kv beta 1.1 subunit of a A-type K<+> channel decreases the slow afterhyperpolarization (sAHP) of hippocampal CA1 neurons and improves learning and memory in hippocampus-dependent tasks: Importantly, young mutants do not show this improvement indicating that the inihibition of Kv beta 1.1 mediates the effects of age-related loss of learning ability and memory. Thus, in one embodiment this invention provides assays for modulators of Kv beta 1.1.
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申请公布号 |
WO0024871(A2) |
申请公布日期 |
2000.05.04 |
申请号 |
WO1999US25011 |
申请日期 |
1999.10.25 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
SILVA, ALCINO, J.;GIESE, KARL, PETER |
分类号 |
C07K14/705;C12N15/85;(IPC1-7):C12N/ |
主分类号 |
C07K14/705 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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