NiSOD-like compound and its derivatives for suppressing abnormal protein aggregation, recovering cell viability, increasing mature neuron number and neurite outgrowth length and protecting dopaminergic cells by reducing oxidative stress or reactive oxygen species in brain tissues

摘要

The accumulation of abnormal proteins in neurodegenerative disorders is considered to induce oxidative stress and lead to cell death. Thus suppression of abnormal protein aggregation and reducing oxidative stress or reactive oxygen species (ROS) are expected to inhibit a wide range of harmful downstream events, providing an observation for identifying the potential prevention and treatment of neurodegenerative disorders comprising spinocerebellar ataxia (SCA), Alzheimer's disease (AD) or Parkinson's disease (PD). In the present invention, there are several cell and animal experiment models for SCA, AD and PD established, and NiSOD-like compounds were applied to these experiment models. The results have demonstrated how NiSOD-like compounds are likely to work in suppressing abnormal protein aggregation, recovering cell viability, increasing mature neuron number and neurite outgrowth length and protecting dopaminergic cells by reducing oxidative stress or reactive oxygen species in brain tissues.

主权项

1. A NiSOD-like compound ([NiH2BDPP(L)]2+) or derivatives thereof represented by structural formulas as follows: L is acetonitrile, water or tert-butyl isocyanate;wherein the NiSOD-like compound or derivatives thereof suppress abnormal protein aggregation, recover cell viability, increase mature neuron number and neurite outgrowth length and protect dopaminergic cells by reducing oxidative stress or reactive oxygen species (ROS) in brain tissues.