ASSAY METHODS FOR THE DETERMINATION OF FKBPL EXPRESSION LEVEL IN THE CONTEXT OF BREAST CANCER

摘要

Disclosed are methods that employ FKBPL as a marker for a subject's sensitivity to endocrine therapies in the treatment of cancers, and as a predictive marker of cancer progression and disease free survival in relation to hormone responsive cancers.

主权项

1. A method of characterising a cancer tissue comprising
determining in a test biological sample an expression level of at least one of FKBPL, a FKBPL variant, and a fragment FKBPL or an FKBPL variant; comparing the determined level of FKBPL to a control standard or the expression of FKBPL, or a FKBPL variant or a fragment thereof in a control sample; determining whether there is a differential expression of FKBPL in the sample as compared to the control standard or the expression of FKBPL in a control sample; and characterising the cancer tissue, wherein characterising the cancer tissue is the determination as to whether an agent, which selectively modulates an oestrogen receptor present in a cancer tissue or lowers the circulating levels of oestrogen in a cancer tissue will decrease the progression of the cancer, or the likelihood of the subject including the cancer tissue to have cancer disease free survival.