DETECTION OF ANALYTES USING METAL NANOPARTICLE PROBES AND DYNAMIC LIGHT SCATTERING

摘要

Disclosed herein are systems and methods for detecting Chemical Species, Biomolecules and Biotargets (Analytes) using receptor functionalized metal nanoparticles and Dynamic Light Scattering.

主权项

1. An assay method for the detection of an analyte, said method comprising:
providing a plurality of probes, said probes comprising metal nanoparticles; contacting a sample solution suspected of including at least one analyte with said plurality of probes to form an assay solution, wherein in a presence of said analyte, a portion of said probes in said assay solution become aggregated nanoparticles; directing light toward said assay solution; and obtaining DLS data from said assay solution using dynamic light scattering, wherein said DLS data indicates a change in average particle size and/or a change in particle size distribution when said analyte is present in said solution.