发明名称 |
COMPUTATIONALLY OPTIMIZED BROADLY REACTIVE ANTIGENS FOR H1N1 INFLUENZA H1N1 |
摘要 |
The generation of optimized H1N1 influenza HA polypeptides for eliciting a broadly reactive immune response to H1N1 influenza virus isolates is described. The optimized HA polypeptides were developed through a series of HA protein alignments, and subsequent generation of consensus sequences, based on selected H1N1 viruses isolated from 1918-2012. Optimized H1N1 HA polypeptides, and compositions, fusion proteins and VLPs comprising the HA polypeptides are described. Condon-optimized nucleic acid sequences encoding the HA polypeptides are also described. Methods of eliciting an immune response against influenza virus in a subject are also described. |
申请公布号 |
HK1212708(A1) |
申请公布日期 |
2016.06.17 |
申请号 |
HK20160100529 |
申请日期 |
2016.01.18 |
申请人 |
University of Pittsburgh - Of the Commonwealth Sys |
发明人 |
ROSS, Ted, M.;CARTER JR., Donald, M.;CREVAR, Corey, J. |
分类号 |
C07K;A61K;C12N |
主分类号 |
C07K |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|