| 发明名称 |
HUMAN MONOCLONAL ANTIBODIES AGAINST THE MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS (MERS-COV) AND ENGINEERED BISPECIFIC FUSIONS WITH INHIBITORY PEPTIDES |
| 摘要 |
The invention provides polypeptides (e.g., antibodies) and fusion proteins that target a epitope in the receptor binding domain (RBD) of the spike (S) glycoprotein of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV). The polypeptides and fusion proteins can be used to treat and prevent MERS-CoV infection in mammals. |
| 申请公布号 |
US2016264647(A1) |
申请公布日期 |
2016.09.15 |
| 申请号 |
US201415030165 |
申请日期 |
2014.10.16 |
| 申请人 |
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERV ;THE UNIVERSITY OF HONG KONG |
发明人 |
Dimitrov Dimiter S.;Ying Tianlei;Ju Tina W.;Yuen Kwok Yung |
| 分类号 |
C07K16/10;C12N7/00;G01N33/569;C07K14/005;A61K39/42;A61K45/06 |
主分类号 |
C07K16/10 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A polypeptide comprising:
(a) the amino acid sequences of SEQ ID NOs: 3-8; (b) the amino acid sequences of SEQ ID NOs: 4 and 11-15; or (c) the amino acid sequences of SEQ ID NOs: 11 and 18-22. |
| 地址 |
Bethesda MD US |
