| 摘要 |
<p>1,249,488. 5 - Chlorophenyl - 5 - hydroperoxy - 2,3 - dihydro - 5H - imidazo - [2,1-a]- isoindoles. SANDOZ Ltd. 12 Dec., 1968 [18 Dec., 1967; 23 July, 1968], No. 59064/68. Heading C2C. Novel 5 - chlorophenyl - 5 - hydroperoxy- 2,3 - dihydro - 5H - imidazo - [2,1-a] - isoindoles of the general formula wherein R 1 is a hydrogen or chlorine atom, are prepared by oxidation of a 5-chlorophenyl-2,3- dihydro - 5H - imidazo - [2,1-a] - isoindole of the general formula with oxygen at a temperature of from 15‹ to 35‹ C. in an ether or C 1-4 alkanol solvent The 5 - chlorophenyl - 5 - hydroperoxy - 2,3- dihydro - 5H - imidazo - [2,1-a] - isoindoles of the first general formula above may be agitated in a solvent at a temperature of from 15‹ to 35‹ C. to produce 5-chlorophenyl-5-hydroxy- 2,3 - dihydro - 5H - imidazo - [2,1-a] - isoindoles of the general formula Pharmaceutical compositions having appetite depressant activity comprise, as active ingredient, a 5-chlorophenyl-5-hydroperoxy-2,3-dihydro - 5H - imidazo - [2,1-a] - isoindole of the first general formula above, together with a pharmaceutically acceptable diluent or carrier, and may be administered orally or parenterally.</p> |
