Verfahren zum schrittweisen Abbau von Peptidketten

摘要

An improvement in the process of sequentially degrading peptide chains in a reaction vessel by successive coupling and cleavage reaction steps, wherein the vessel is subjected to a vacuum purging operation between the reaction steps to remove undesired materials. The improvement involves flushing the vessel with a stream of nitrogen gas while it is under vacuum whereby the undesired materials are more rapidly and more completely removed from the vessel and the cumulative yield of the process is increased.