| 摘要 |
PURPOSE:To provide a nervous cell alteration-repairing agent especially having an activity to stimulate the survival and growth of the choline-acting nervous cells of central nervous system and useful for the treatment of geriatric dementia, etc., by containing a secoaromadendrane type sesquiterpene, etc., as an active ingredient. CONSTITUTION:The agent contains at least one compound selected from a secoaromadendrane type sesquiterpene of formula I (R<1> is formyl; R<2> is group of formula II; R<1> and R<2> may be bonded to each other to form a group of formula III, IV, etc.) and a compound of formula V in an amount of 1-70wt.%, preferably 1-30wt.%, as an active ingredient. The ingredient is suitably mixed with conventional carrier, diluent, excipient, etc., and subsequently prepared by a conventional method to provide the objective agent. The agent is prepared in the form of tablets, granules, capsules, injection, etc., and administered in a dose of 10-800mg/kg/day as the compound of the active ingredient. |
