The invention concerns a granulocyte-inhibiting polypeptide in purified form, which has a molecular weight of 27 to 29 kD, an isoelectric point of 4.0 to 4.5 and the following amino acid sequence (I) on the terminal N: Asp-Ile-Val-Met-Thr-Gln-Ser-Pro-Gly-Thr-Leu-Ser-Pro-Gly-Glu-Arg-Ala-Th r--, a process for producing this polypeptide and a diagnostic process for in vitro detection of immunosuppression in uremic patients whose sera contain this polypeptide.
申请公布号
DE4125188(A1)
申请公布日期
1992.02.13
申请号
DE19914125188
申请日期
1991.07.30
申请人
MERCK PATENT GMBH, 6100 DARMSTADT, DE
发明人
BLOCK, LUTZ H. PROF. DR., 7819 DENZLINGEN, DE;HOERL, WALTER H. PROF. DR. DR., 7800 FREIBURG, DE;NEUMANN, SIEGFRIED, DR., 6104 SEEHEIM-JUGENHEIM, DE
