(+)-3-substituted-N alkylmorphinans, synthesis and use as anticonvulsant and neuroprotective agents

摘要

It has been discovered that certain (+)-3-substituted-N-alkylmorphinans are effective anticonvulsant and neuroprotective agents. Novel compounds having these biological properties are presented in a method of use for preventing, treating or controlling convulsions in mammals having a need for such treatment. The compounds do not lead to dependency, have low toxicity, and provide effective anticonvulsant or neuroprotective treatment with little or no behavioral detriment to the recipient. A number of pharmacological formulations and methods of administering compounds of the invention are suitable for anticonvulsive or neuroprotective treatments.