| 摘要 |
PURPOSE: To obtain a medicine containingα- andγ-thujaplicins as active ingredients and capable of suppressing the release of active oxygen or removing the released active oxygen species. CONSTITUTION: This scavenger for active oxygen contains at least one comprisingα-thujaplicin and its salt andγ-thujaplicin and its salt as active ingredients. The ingredients are good in stability and excellent in persistence without any side effects. Theα-thujaplicin or its salt is excellent in scavenging actions, especially on hydrogen peroxide and singlet oxygen. The scavenger can be prepared into a peroral agent, a suppository, a parenteral injection, etc., and further a lotion, a cream, an ointment, etc., by suitably blending a filler, an extender, a binder, a humectant, a disintegrating agent, a surfactant, a lubricant, etc., therewith. The scavenger has preventing and lowering actions on in vivo production of peroxylipids and is effective in preventing and treating diseases due to blood platelet aggregation, inflammation, arteriosclerosis, etc. The daily dose thereof is 1-10mg/kgα- andγ-thujaplicins.
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