发明名称 |
REDUCING TOXIC EFFECTS OF CARBOPLATIN USING DITHIOETHERS |
摘要 |
To reduce the toxic effect of carboplatin, particularly myelosuppression and emesis, a dithioether having the formula (I) R1-(CH2)n-S-S-(CH2)m-R2 wherein each of R1 and R2 individually is SO3H or PO3H2; and each of m and n is individually 1, 2, 3 or 4; or a pharmaceutically acceptable salt thereof, preferably disodium 2,2'-dithiobis(ethane sulfonate) (dimesna), is administered in combination with carboplatin to a patient, at substantially the same time or sequentially, whereby the dithioether and the carboplatin become copresent in the blood of the patient. Compositions comprising carboplatin and the dithioether are included in the invention.
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申请公布号 |
CA2263166(A1) |
申请公布日期 |
1998.03.26 |
申请号 |
CA19972263166 |
申请日期 |
1997.09.23 |
申请人 |
BIONUMERIK PHARMACEUTICALS, INC. |
发明人 |
SEETHARAMULU, PEDDAIAHGARI;HAUSHEER, FREDERICK H.;MURALI, DHANABALAN;REDDY, DASHARATHA G.;HARIDAS, KOCHAT |
分类号 |
A61K31/555;A61P35/00;(IPC1-7):A61K31/555 |
主分类号 |
A61K31/555 |
代理机构 |
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