IMIDAZOLIDYLIC MACROLIDE OR ITS ISOMERS, OR ITS PHARMACEUTICALLY ACCEPTABLE SALT, METHODS OF ITS SYNTHESIS AND PHARMACEUTICAL COMPOSITION SHOWING IMMUNOSUPPRESSIVE ACTIVITY

摘要

FIELD: organic chemistry, heterocyclic compounds. SUBSTANCE: product: imidazolidylic macrolide of the formula (I): where R - group where: G means NR ; R has values indicated for R , H, (C1-C10)-alkyl; R - H, OH; R - H; R - methyl, ethyl or propyl; R - H, (C1-C6)-alkyl possibly substituted with phenyl that can be substituted with halogen; R and R are taken independently from H, (C1-C7)-alkyl, R14O(CH2)m- where R14- - H or (C1-C6)-alkyl; m = 0, 1, 2, 3; groups phenyl--(CH2)m- and phenyl group can be substituted with substituents X, Y, Z; A is taken from group involving: (C1-C10)-alkyl, group where s = 0-6, t = 0-6; Q - H; W - oxygen atom; X, Y and Z are taken independently from group involving: H, (C1-C10)-alkyl, halogen atom, trifluoromethyl, group R16O(CH2)m- where R - H, (C1-C6)-alkyl, hydroxy-(C2-C3)-alkyl, -CF3 and m = 0, 1, 2 or 3; or two of substituents X, Y and Z can be bound each with other and form five-membered saturated ring involving 2 oxygen atoms and 3 carbon atoms; n = 2. Invention proposes also two methods of synthesis of compounds (I) and pharmaceutical composition based on thereof. Synthesized compounds show IMMUNOSUPPRESSIVE activity. EFFECT: improved method of synthesis. 8 cl, 2 tbl+