发明名称 |
OPTICALLY ACTIVE 1,4-BENZODIOXINE-2-CARBOXYLIC ACID DERIVATIVES AND PROCESS FOR PRODUCING THE SAME |
摘要 |
Optically active alcohols represented by general formulae (I, II) which are useful as intermediates in the synthesis of (RRR)-optical isomers of 1,4-benzooxine-2-carboxylic acid derivatives which are useful as preventives and remedies for diabetes, obesity, etc. A process for efficiently producing at a high yield (RRR)-optical isomers of 1,4-benzooxine-2-carboxylic acid derivatives starting with the above optically active alcohols via compounds of general formulae (V, VII). In said formulae, R represents (R)-1-phenylethylamino or (S)-1-phenylethylamino; Y represents halogeno, C1-4 alkylsulfonyl or arylsulfonyl; and R2 and R3 represent each hydrogen or a substituent such as alkyl, or R2 and R3 together represent -OCH2O-.
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申请公布号 |
WO0006562(A1) |
申请公布日期 |
2000.02.10 |
申请号 |
WO1999JP03963 |
申请日期 |
1999.07.23 |
申请人 |
NISSHIN FLOUR MILLING CO., LTD.;KAWAMURA, KOJI;UENO, MASAHIRO;SUZUKI, MASASHI;YANAI, MAKOTO;TAKAHASHI, TOSHIHIRO;ITOH, KOICHI |
发明人 |
KAWAMURA, KOJI;UENO, MASAHIRO;SUZUKI, MASASHI;YANAI, MAKOTO;TAKAHASHI, TOSHIHIRO;ITOH, KOICHI |
分类号 |
C07D319/20;C12P17/06;C12P41/00;(IPC1-7):C07D319/20;A61K31/335 |
主分类号 |
C07D319/20 |
代理机构 |
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