| 摘要 |
PROBLEM TO BE SOLVED: To obtain the subject composition capable of further stabilizing a solid drug preparation for internal use comprising a benzimidazole-based compound by formulating the benzimidazole-based compound and a specific substance. SOLUTION: This composition is obtained by formulating (A) a benzimidazole- based compound of formula I (Het1 is of formula II; Het2 is of formula III; R1 and R2 are each H, methoxy or difluoromethoxy; R3 is H or sodium, R4 to R6 are each H, methyl, methoxy, methoxypropoxy or trifluoroethoxy) (e.g. rabeprazole of formula IV) with (B) a substance selected from e.g. a sodium carbonate, sodium hydroxide, potassium hydroxide, crospovidone, at preferably 0.01-20 pts.wt per pt.wt. of the ingredient A. It is also possible to make a drug preparation by coating a core composed of the above composition with an intermediate film, enteric film or moistureproof film.
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