| 摘要 |
<p>Implantable antimicrobial medical devices comprise one or more antimicrobial reservoirs, each such reservoir comprising one or more porous, hydrophobic cores which incorporate antimicrobial substances in predetermined distributions for timed release in vivo. Predetermined distributions of antimicrobial substances incorporated in antimicrobial reservoir cores are achieved through use of supercritical fluid solvent carriers. Precipitation of antimicrobial substances from such solvent carriers in predetermined distributions is accomplished through application of heating, cooling or decreased ambient pressure to the solvent carriers.</p> |
