| 摘要 |
The invention relates to the use of a compound, selected from 3-[4-(4-phenyl-1,2-3,6-tetrahydro-1-pyridyl)butyl]indole-5-ol, 1-(2-(bis(4-fluorophenyl)methoxy)ethyl)-4-(3-phenyl-propyl)piperazine, 1-(4-hydroxyphenyl)-2-(4-benzyl-1-piperidinyl)propanol, 3-(4-((3S)-3-benzyl-1-piperidyl)butyl)indole-5-carbonitril, 3-(4-((3R)-3-benzyl-1-piperidyl)butyl)indole-5-carbonitril, 6-(4-(4-(5-fluoro-3-indolyl)butyl)-1-piperazinyl)-2H-1-benzopyrane-2-one, (5S)-(-)-5-[4-(4-aminobenzyl)-1-piperidylmethyl]-3-(4-ethylphenyl)oxazolidine-2-one, 6-{3-[4-(2,4-difluorobenzyl)-1-piperidyl]-1-oxopropyl}-2,3-dihydrobenzoxazole-2-one, 3-(4-(3-(4-fluorophenyl-hydroxymethyl)piperido-1-yl)butyl)-5-indole-carbonitril, 2-(4-[3-(5H-dibenz[b,f]azepine-5-yl]propyl]-1-piperazinyl)ethanol, 1-[2-(3,4-dimethoxyphenyl)ethyl]-4-(3-phenylpropyl)piperazine, (5S)-(-)-5-(4-benzyl-1-piperidylmethyl)-3-(4-chlorophenyl)oxazolidine-2-one, 6-{3-[4-(4-fluorobenzyl)-1-piperidyl]-2-methylpropionyl}-2,3-dihydrobenzoxazole-2-one, (1R,2S)-(+)-4-(3-(4-benzyl-piperidino-1-yl)-1-hydroxy-2-methyl-propyl)phenol, (E)-4-(3-(4-benzyl-piperidino-1-yl)-2-methyl-propenyl)phenol, 3-(4-(4-(2,1,3-benzothiadiazole-5-yl)-1-piperazinyl)butyl)indole-5-carbonitril, 6-(3-(4-(4-fluorobenzyl)-1-piperidyl)-2-propenyl)-2,3-dihydrobenzoxazole-2-one, 3-(4-trifluoromethylphenoxymethyl)pyrrolidine, 6-{3-[4-(4-fluorobenzyl)-1-piperidyl]-propionyl}-3H-benzothiazole-2-one, 4-{3-[4-fluorobenzyl)piperidino-1-yl]propoxy}phenol, [2-(4-methoxy-3-phenethyloxy-phenyl)ethyl]dipropyl-amine, (1S,5R)-3-(2-(2-adamantyl)ethyl-1,8,8-trimethyl-3-azabicyclo[3.2.1]octane, 6-{3-[4-(2,4-difluorobenzyl)piperidino-1-yl]propionyl}-3H-benzothiazole-2-one, 1-{1-[2-(4-fluoro-phenyl)ethyl]piperidino-4-yl}indane-1-ol, 1-[2-(4-fluoro-phenyl)ethyl]-4-(naphthalino-2-sulfinyl)piperidine, 1-(indole-4-yl)-4-[4-(4-fluorophenyl)butyl]piperazine, 3-(4-(2-(2-phenyl-ethyl)-1-piperidyl-1-butyl)indole, 2-[4-(4-(3-indolyl)butyl)-1-piperazinyl]benzonitrile, (S)-(-)-5-[4-hydroxy-4-(3,4-methylenedioxyphenyl)piperidino-1-ylmethyl]-3-(4-methoxyphenyl)oxazolidine-2-one, 5-fluoro-3-[4-phenyl-1-piperidyl)butyl]indole, 3-(1-phenethyl-1,2,3,6-tetrahydro-4-pyridyl)indole-5-carbonitril, 3-(2-phenylethyl)-1,2,3,4,5,6-hexahydrobenz[f]isoquinoline, 5-fluoro-3-(1-phenethyl-4-piperidyl)indole, N-(1-benzyl-4-piperidyl)-6-fluoro-1,2,3,4-tetrahydrocarbazolo-3-carboxamide, 3-(4-(4-(4-cyanophenyl)-1-piperazinyl)butyl)indole-5-carbonitril, 3-(3-(4-(2-carbamoyl-5-benzofuranyl)-1-piperazinyl)propyl)indole-5-carbonitril, 3-(4-(4-(4-fluorophenyl)-1-piperazinyl)butyl)indole-5-carbonitril, 3-(4-(4-(2-cyanophenyl)piperazinyl)butyl)indole-5-carbonitril, 5-[3-[4-(-fluorobenzyl-1-piperidyl)-1-oxopropyl]-6-fluoro-2,3-dihydro-1H-benzimidazole-2-one, 6-(3-[4-(4-fluorobenzyl)-1-piperidyl]-1-oxopropyl)-2,3-dihydrobenzoxazole-2-one, 3-(4-benzyl-1-piperidyl)-1-(4-hydroxyphenyl)-1-propanone, 3-(4-(4-(4-fluorophenyl)-1-piperazinyl)butyl)indole-5-carbonitril, 6-(3-[4-(4-fluorobenzyl)-1-piperidyl]-1-hydroxypropyl)-2,3-dihydrobenzoxazole-2-one, 1-(2-methoxyphenyl)-4-(2-(6,7,8,9-tetrahydro-5H-benzocycloheptene-6-ylidene)ethyl)piperazine, 3-(1-(2-(4-fluorophenoxy)ethyl)-4-piperidyl-4,5-dihydro-2H-benz[g]indazole, (5S)-(-)-5-(4-(4-fluorobenzyl)-1-piperidylmethyl)-3-(4-fluorophenyl)oxazolidine-2-one, 3-(4-((3R)-3-benzyl-1-piperidyl)butyl)-5-fluoroindole, 3-(4-((3S)-3-benzyl-1-piperidyl)butyl-5-fluoroindole, or the corresponding acids, bases or salts for use as a sigma receptor ligand and/or for combatting carcinoma or sarcoma. |
