EXTRACTIVE PURIFICATION OF LIPOPEPTIDE ANTIBIOTICS

摘要

The present invention provides a rapid and inexpensive method for extractive ly isolating acidic lipopeptide antibiotics in high yield and purity. The lipopeptide antibiotics, which can be cyclic depsipeptides or cyclic peptide s, are extracted by contacting an aqueous solution of the lipopeptide antibioti c and a divalent metal ion with an organic solvent, and then contacting the organic solvent extract of the lipopeptide antibiotic with acid. Alternatively, an acidic lipopeptide antibiotic is partitioned from an aqueo us solution into an organic solvent and is then recovered from the organic solvent.