发明名称 |
Substituted 8-Pyridinyl-6,7,8,9-Tetrahydropyrimido¬1,2-a Pyrimidin-4-one and 8-Phenyl-6-7,8,9-Tetrahydropyrimido¬1,2-a Pyrimidin-4-one derivatives |
摘要 |
<p>The invention relates to substituted-pyrimidone derivatives represented by formula (I) or a salt thereof: <CHEM> wherein: X represents two hydrogen atoms, a sulfur atom, an oxygen atom or a C1-2 alkyl group and a hydrogen atom; Y represents a bond, a carbonyl group, a methylene group optionally substituted; R1 represents a 2, 3 or 4-pyridine ring or a 2, 4 or 5-pyrimidine ring, the rings being optionally substituted; R2 represents a phenyl group or a naphthalene ring; the phenyl group and the naphthalene ring being optionally substituted; R3 represents a hydrogen atom or a C1-6 alkyl group; R4 represents a phenyl group, a pyridinyl group or a naphthalene ring, the groups and the ring being optionally substituted; R5 represents a hydrogen atom, a C1-6 alkyl group or a halogen atom; n represents 0 to 3; and p+q=0-3. <??>The invention relates also to a medicament comprising the said derivative or a salt thereof as an active ingredient which is used for preventive and/or therapeutic treatment of a neurodegenerative disease caused by abnormal activity of GSK3 beta , such as Alzheimer disease.</p> |
申请公布号 |
EP1460075(A1) |
申请公布日期 |
2004.09.22 |
申请号 |
EP20030290727 |
申请日期 |
2003.03.21 |
申请人 |
SANOFI-AVENTIS;MITSUBISHI PHARMA CORPORATION |
发明人 |
LOCHEAD, ALISTAIR W.;SAADY, MOURAD;SLOWINSKI, FRANCK;YAICHE, PHILIPPE |
分类号 |
A61K;A61K31/519;A61P25/00;C07D;C07D487/04;(IPC1-7):C07D487/04 |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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