DIAGNOSIS OF RESPIRATORY TRACT INFECTIOUS DISEASE USING BLOOD SPECIMENS

摘要

Provided are a method for detecting respiratory infection associated with bacterial infection, a method for selecting patients with respiratory infection to receive an antibiotic, and a method for determining the timing for ending administration of an antibiotic to a patient with respiratory infection receiving the antibiotic, wherein said methods are characterized in that they are able to appropriately select patients with respiratory infection to whom the antibiotic is to be administered, to adjust the administration period of the antibiotic, and to treat respiratory infection associated with bacterial infection, and in which a measured value of sCD14-ST in blood is used as an indication.

主权项

1. A method for detecting a respiratory infection associated with a bacterial infection in a subject in need thereof, comprising:
(1) measuring soluble CD14 antigen subtype (“sCD14-ST”) in a blood sample derived from the subject; (2) comparing a measured value of sCD14-ST with a cutoff value; (3) discriminating between bacterial and viral infections based on the measured value of sCD14-ST; wherein an increase in said measured value of sCD14-ST compared to said cutoff value is indicative of the respiratory infection associated with the bacterial infection and a decrease in said measured value of sCD14-ST compared to said cutoff value is indicative of the respiratory infection associated with the viral infection; wherein said cutoff value is more than 577 pg/mL; wherein the sCD14-ST is measured by a sandwich immunoassay system comprising:
(a) an antibody binding to a peptide comprising an amino acid sequence of SEQ ID No: 2, and(b) an antibody binding to a peptide comprising an amino acid sequence from positions 17 to 26 of SEQ ID NO: 3.