ANTI-CD3 ANTIBODIES, ACTIVATABLE ANTI-CD3 ANTIBODIES, MULTISPECIFIC ANTI-CD3 ANTIBODIES, MULTISPECIFIC ACTIVATABLE ANTI-CD3 ANTIBODIES, AND METHODS OF USING THE SAME

摘要

The invention relates generally to antibodies, activatable antibodies, multispecific antibodies, and multispecific activatable antibodies that specifically bind to at least CD3, as well as to methods of making and using these antibodies, activatable antibodies, multispecific antibodies, and/or multispecific activatable antibodies in a variety of therapeutic, diagnostic and prophylactic indications.

主权项

1. An isolated single chain variable antibody fragment that binds the epsilon chain of CD3 (CD3ε) comprising a variable heavy chain complementarity determining region 1 (VH CDR1) comprising the amino acid sequence TYAMN (SEQ ID NO: 53); a variable heavy chain complementarity determining region 2 (VH CD2) comprising the amino acid sequence RIRSKYNNYATYYADSVKD (SEQ ID NO: 54); a variable heavy chain complementarity determining region 3 (VH CDR3) comprising the amino acid sequence HGNFGNSYVSWFAY (SEQ ID NO: 55), a variable light chain complementarity determining region 1 (VL CDR1) comprising the amino acid sequence RSSTGAVTTSNYAN (SEQ ID NO: 56); a variable light chain complementarity determining region 2 (VL CDR2) comprising the amino acid sequence GTNKRAP (SEQ ID NO: 57); and a variable light chain complementarity determining region 3 (VL CDR3) comprising the amino acid sequence ALWYSNLWV (SEQ ID NO: 58).