POLYMER CONJUGATES OF OPIOID ANTAGONISTS

摘要

The invention provides polymer conjugates of opioid antagonists comprising at least one polymer backbone, such as poly(ethylene glycol), covalently attached to a residue of an opioid antagonist. The linkage between the polymer and the opioid antagonist is preferably hydrolytically stable. The invention also includes a method of treatment of one or more side effects associated with the use of opioid analgesics, such as constipation, nausea, or pruritus, by administering a polymer conjugate of the invention.