发明名称 | Human antibodies to respiratory syncytial virus F protein and methods of use thereof | ||
摘要 | The present invention provides fully human antibodies that bind to respiratory syncytial virus F protein, compositions comprising the antibodies and methods of use. The antibodies of the invention are useful for preventing fusion of the virus with the cell membrane and preventing cell to cell spread of the virus, thereby providing a means of preventing the infection, or treating a patient suffering from the infection and ameliorating one or more symptoms or complications associated with the viral infection. The antibodies may also be useful for diagnosis of an infection by RSV. | ||
申请公布号 | US9447173(B2) | 申请公布日期 | 2016.09.20 |
申请号 | US201414207797 | 申请日期 | 2014.03.13 |
申请人 | Regeneron Pharmaceuticals, Inc. | 发明人 | Gurnett-Bander Anne;Perez-Caballero David;Sivapalasingam Sumathi;Duan Xunbao;MacDonald Douglas |
分类号 | C07K16/10;A61K39/42;A61K39/155;A61K45/06;G01N33/569 | 主分类号 | C07K16/10 |
代理机构 | Alston & Bird LLP | 代理人 | Alston & Bird LLP ;Mallon Veronica |
主权项 | 1. An isolated human antibody or antigen-binding fragment thereof that binds specifically to RSV-F, wherein the antibody or antigen-binding fragment comprises three heavy chain complementarity determining regions (CDRs) (HCDR1, HCDR2 and HCDR3) contained within any one of the heavy chain variable region (HCVR) amino acid sequences selected from the group consisting of SEQ ID NO: 2, 18, 34, 50, 66, 82, 98, 114, 130, 146, 162, 178, 194, 210, 226, 242, 258, 274, 290, 306, 322 and 338; and comprises three light chain CDRs (LCDR1, LCDR2 and LCDR3) contained within any one of the light chain variable region (LCVR) amino acid sequences selected from the group consisting of SEQ ID NOs: 10, 26, 42, 58, 74, 90, 106, 122, 138, 154, 170, 186, 202, 218, 234, 250, 266, 282, 298, 314, 330 and 346. | ||
地址 | Tarrytown NY US |