| 摘要 |
PROBLEM TO BE SOLVED: To obtain an anti-pruritus agent inducting slight side effect by making the agent contain oleanolic acid 3-O-monodesmoside as an active component. SOLUTION: This medical agent contains oleanolic acid 3-O-monodesmoside introduced from momordin Ic derived from Jifushi (dried fruit of Chenopodium scoparia L.), momordin I derived from Mokubekkon (dried root of Momordica cochinchinensis Spreng.), and chikusetsu saponin V derived from Panax ginseng, Panax japonicum, etc., as an active component. The agent is further added with known additives, as necessary, mixed and prepared to a peroral or a parenteral agent by usual methods. An administration dose of the active component is daily about 0.1-1 mg/kg of oleanolic acid 3-O-monodesmoside. The oleanolic acid 3-O-monodesmoside also has excellent antiallergic action and anti-inflammatory action and is useful for treating prurigo, dermal pruritus, eczema, dermatitis, urticaria, allergic rhinitis, allergic conjuctivitis, immediate asthma, etc., as an anti-pruritus agent collectively having the actions. |
